Santarelli

This paper is very interesting in how it tries to explain why neurogenesis in the hippocampus might be the reason antidepressants work. I think that this connection is  demonstrated well when they irradiated the hippocampus in some of the mice in the study and how they did not have a strong response in the novelty suppressed feeding while being administered antidepressants in contrast mice(non irradiated) that were given antidepressants  did have a more positive outcome with the nsf. I also think that it was good that they had another group that was exposed to the radiation to try and rule out the simple presence of radiation in the brain as being the cause for the lack of effectiveness of antidepressants. And with all those factors combined it seems  to suggest that antidepressants partly work because of neurogenesis in the hippocampus. If there is something to criticize about this study I would maybe say that there isn't enough behavioral measures that were conducted in order to be able to point and say that he’s able to further show that he’s proving that it is depressive behavior that is being demonstrated and not just one or two behaviors that are associated with depression .

I also found it interesting when they showed that by knocking out 5ht1a neurons that it hinders the effectiveness of fluoxetine(ssri) but not the other antidepressant drugs and i think if I am reading correctly that it also hindered cell proliferation while the other antidepressants kept proliferating I think that interesting because that might mean that there are different ways in increasing neurogenesis. And exemplifies that there might potentially be more things that need to be studied around drugs and neurogenesis.